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Regarding the synthesis of thyroid hormones, which statement is INCORRECT?

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  1.  iodine undergoes rapid oxidation following entry to thyroid cells

  2.  the iodine pump is the major source of iodine for hormone synthesis

  3.  TSH increases iodine uptake by the thyroid gland

  4.  thiocyanate and ouabain decrease iodine uptake by the thyroid gland

  5.  it involves iodination of thyrosine residues in thyroglobulin

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